Determining diagnostic markers of intrautering growth retardation in early pregnancy

Intrauterine growth restriction is the cause of significant increases in perinatal mortality, morbidity and problems development newborns infants. The leading place this pathology not accidental, because according to various authors, frequency loss associated with it from 19 287‰ more, level - 58.7 88.0%.The objective: To determine certain serum ultrasound markers during first trimester pregnancy improve mortality rate women intrauterine restriction. Materials methods. A prospective study pregnant gestation period 11 weeks 0 days – 13 6 days, which was plasma protein (PAPP-A), mean platelet volume (MPV), placenta examination. Pregnant were divided into 2 groups: main group (n1-52) control (n2-50). consisted a low PAPP-A changes towards their increase. It that more sensitive, our opinion, for placental disorders occurrence fetal retardation.Results. In study, PAPP-А levels 39 <0.5 MoM, WTO 36 cases were> 10 fl, which, literature, can be used as early prediction ZRP.Ultrasound type stage trophoblast invasion described intra- / or periplacental pathological areas, considered causes insufficiency, results risk ZRP. According high specificity sensitivity Doppler parameters determination indices (PI IR) uterine arteries established. Conclusions. showed performing screening based on detailed history determining PAPP-A, MPV, examination at IUGR allows prophylactic treatment monitoring thus reduces neonatal mortality.